Przydrujsk (Lat. Piedruja) is located within the borders of the Latvian state. Its history is inextricably linked to Druja, even though the two towns, separated by the Dvina River, lie in two states (Latvia and Belarus respectively). Before 1500, the area belonged to indigent boyars who were in the service of mighty lords serving the owners of the Polotsk land. In 1506. Druja and the surrounding territories were granted to Anna of Sapieha, Duchess of Massalskaya, widow of Timothy killed in the Battle of Vedrosha in 1499, and their sons Peter, George and Ivan. The same grant also freed the Druj landowners from their obligations to the Polotsk castle. On 11 January 1611, Tymoteusz's great-granddaughter Dorota and her husband sold their estate to Duke Lviv Sapieha (1557-1633), Grand Chancellor of Lithuania, and in 1824, Duke Franciszek Sapieha sold the estate to Jozef Milosz, who first ruled the area himself, followed by his son Eugene. Dorota Janiszewska-Jakubiak cites the poet's family history after the author of the article 'Latvian Traces in Czesław Miłosz's Family' (Marek Głuszko):

"Among his ancestors, Czeslaw Milosz mentions Józef Milosz, born probably around 1790. This Josef Milosz left his native land near Kėdainiai and took up service as a court official (estate manager) at the Sapieha princely residence in Drua on the Daugava River. This is the moment when the Miłosz line split into two separate ones: Lithuanian, as Józef Miłosz's brothers remained in Serbinia, and Belarusian. The Sapiehs were forced by the tsarist authorities to sell their estates (according to family tradition, they refused to swear loyalty to the tsar). A significant part of the Druzhskoe estate (30,000 hectares) was purchased by this Józef Miłosz, who had previously managed it. Thus, from 1824, the Milosz family became the owners of a sizable estate, whose main centres were Druja and Chereja. The estate also extended to the other, Kurland side of the Dvina, including Przydrujsk (Lat. Piedruja)'.

Before 1633, Duke Leon Sapieha, Voivode of Vilnius and Great Hetman of Lithuania, founded the wooden Church of the Assumption of the Blessed Virgin Mary in Przydruisk and granted land to the clergy. The date is engraved on one of the bells: 1619. It is known that this was already a parish church at the beginning of the 18th century. The estate, which was once the property of the parish, belonged to the state at the end of the 19th century. The brick church was built in 1759-1774 by Karol Karp, canon of Vilnius. It may have been designed by a well-known architect - Antonio Paracca. The temple was consecrated in 1760 by the local dean. A Catholic parish was established here in the early 17th century, when there was no temple yet.

The church preserves the main altarpiece from the 18th century, which is an example of illusionist painting. The centre of the composition is occupied by a copy of a painting by Bartolomeo Murillo made in the 1930s, the architectural part of the altar is crowned by representations painted on tinplate around 1900.

The church suffered damage during the First World War, when the helmets on the towers were destroyed. After the end of the war, Przydruisk became part of independent Latvia. At that time, the building was restored by the local parish priest (1911-1940) - Fr Bronislaw Stefanowicz (1876-1940), whose tomb is located next to the church. After the Second World War, in Soviet times (Piedruja, as well as the whole of Latvia, lay within the borders of the Soviet Union), the church was continuously open.

The church has a single nave, with two towers flanking the facade on the west side. The church is surrounded by a fence with a high gate, and oval chapels are situated on the inside at the four corners.

Between 2014-2018 and 2019, conservators Tomasz Dziurawiec and Agnieszka Chojkowska-Sawicka carried out the conservation of the church. The money for the work was raised by the Cultural Heritage Foundation as part of the competition Cooperation with Poles and Poles Abroad (in 2015 coordinated by the Ministry of Foreign Affairs and since 2016 by the Senate of the Republic of Poland).

In 2014, the partially visible illusionist works decorating the presbytery were examined, and excavations were carried out throughout the church. The result of the comparative analysis made it possible to assume with a high degree of probability that the author of the painting decoration in the main altar was Filippo Castaldi, a painter associated with the Platers.

In 2015, the first stage of conservation work was carried out on the illusionist main altarpiece in the church. A reconnaissance of the temple's presbytery was carried out, where a valuable al fresco painted architectural retable, imitating an altar set, is located on the eastern wall. Its authorship is attributed to Kazimir Antoshevsky, who worked from the early 1880s to the beginning of the 19th century in the north-eastern area of the former Grand Duchy of Lithuania, specialising precisely in the creation of illusionistic wall paintings. The central part of the fresco features a secondary painting of the Assumption of the Blessed Virgin Mary (oil on canvas). The top of the altar is decorated with a fresco depicting the Holy Trinity and two pairs of angels among the clouds. A year later, the polychrome and gilding losses in the upper part of the altarpiece were repaired, and conservation of the painting and frame was carried out. In 2017, conservation work was carried out on the lower part of the illusionist altarpiece and the lower wooden part - the mensa and tabernacle. In 2019, work was carried out on the stalls in the chancel.